Few products have captured(吸引，引起) public interest as fast as GLP-1 receptor-agonist weight-loss drugs. But one unforeseen(未预见到的，意外的) consequence of their popularity has been to create what is, in effect(实际上，实质上), one of the biggest off-label(非标签用药，超说明书用药) medical experiments ever. This is the rapid spread of “microdosing(微剂量服用)”: in other words, of taking less than the recommended amount.
很少有产品能像GLP-1受体激动剂类减肥药那样迅速抓住公众的兴趣。但它们的流行带来了一个未曾预料的后果：实际上催生了有史以来规模最大的非标签用药实验之一。这就是“微剂量服用”的迅速蔓延——即服用低于推荐剂量的药物。
Microdosing has become so popular (one estimate suggests one user in seven has indulged(沉溺，放纵) in it) that in America a whole industry has grown up around(围绕……发展起来) it. It is offered by big online firms such as Noom and Hims & Hers, is also available at lots of smaller medical spas dotted around the country and, most worryingly, is something people often just try for themselves at home.(大型在线公司如Noom和Hims & Hers提供这项服务，全国各地的许多小型医疗水疗中心也提供，而最令人担忧的是，人们常常只是在家自行尝试。)
微剂量服用变得如此流行（一项估计显示，每七名使用者中就有一人尝试过），以至于在美国围绕它形成了一个完整的产业。大型在线公司如Noom和Hims & Hers提供这项服务，全国各地的许多小型医疗水疗中心也提供，而最令人担忧的是，人们常常只是在家自行尝试。
Some microdosing is routine. For example many patients start with a small dose and work up to a full one in order to keep side-effects in check(控制副作用). Conversely, those coming off the drugs might be told to step their doses down gradually rather than going “cold turkey(突然完全停止（成瘾行为）)”. Where things get trickier is when microdosing itself is the goal: to save on the cost of drugs, for example, or through fear of side-effects.(事情变得棘手的地方在于，当微剂量本身成为目标时：例如为了节省药费，或出于对副作用的恐惧。)
有些微剂量服用是常规操作。例如，许多患者从小剂量开始，逐渐增加到全剂量，以控制副作用。相反，那些正在停药的患者可能会被告知逐步减少剂量，而不是突然完全停用。事情变得棘手的地方在于，当微剂量本身成为目标时：例如为了节省药费，或出于对副作用的恐惧。